Structure of PDB 6vl0 Chain A Binding Site BS01

Receptor Information

>6vl0 Chain A (length=429) Species: 37319 (Pseudo-nitzschia multiseries)

ESPKEVLSRVQDAGLTLTNPNDLYWMVDFLKEKYYDNGDYYYPIKTVCDG
ESIDVKFYCPFEPSLSPHYLELYGSRDERASIYETTMKKYNRINSEKTSA
ICTPYSSYGDTQIVAYFYSMMYYINDQTAHLKLPESEIESELIDILNDDI
LIYLNEFMSIFEPEDAQDLERIWDFLDFYQPYFSKVDGKIVLDEKYLVRT
PSQMPLIKTICEYVSEQFAPSKNITQVIWEVVRYIKGVKDEIHIRGDKSF
TLSLQEYDDFRDKVTASPMAHAVSDLTHERFSYEAYTNPAFMELENRCSE
IITYFNDVCTSDRERLDEDPFNSVFILMDLDPSLNFAKSCDVVVEHAYNK
MQAFLKLKEEILESASDEEERLALARMIKTREDSLIGYVLHEVCCVEDGY
ARDHKPLMKAFLEEEITKSLAEKVKFNPV

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 6vl0 Chain A Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6vl0 Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into anN-prenyltransferase.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): N351 T355 E359
• Binding residue (residue number reindexed from 1): N306 T310 E314
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.5.1.-

Gene Ontology

Molecular Function

• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0016036 cellular response to phosphate starvation
• GO:0071244 cellular response to carbon dioxide

External links

• PDB: RCSB:6vl0, PDBe:6vl0, PDBj:6vl0
• PDBsum: 6vl0
• PubMed: 32457155
• UniProt: A0A386KZ50|DABA_PSEMU Magnesium-dependent glutamate N-prenyltransferase (Gene Name=dabA)