Structure of PDB 6vgd Chain A Binding Site BS01

Receptor Information
>6vgd Chain A (length=98) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPGSGQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6vgd Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		R337 R340 Y341 Y343 K350 Y356 Y358
Binding residue
(residue number reindexed from 1)		R63 R66 Y67 Y69 K76 Y82 Y84
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6vgd, PDBe:6vgd, PDBj:6vgd
PDBsum6vgd
PubMed33275876
UniProtQ01543|FLI1_HUMAN Friend leukemia integration 1 transcription factor (Gene Name=FLI1)

[Back to BioLiP]