Structure of PDB 6vfp Chain A Binding Site BS01

Receptor Information
>6vfp Chain A (length=439) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDI
FTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEV
QDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQ
AGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSP
PRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSD
QGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVL
AKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDV
AEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFL
QTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6vfp Chain A Residue 505 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6vfp Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered delta-Protocadherins.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		E9 E10 D59 E61 D106
Binding residue
(residue number reindexed from 1)		E8 E9 D58 E60 D105
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vfp, PDBe:6vfp, PDBj:6vfp
PDBsum6vfp
PubMed32101743
UniProtQ08174|PCDH1_HUMAN Protocadherin-1 (Gene Name=PCDH1)

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