Structure of PDB 6vbz Chain A Binding Site BS01

Receptor Information
>6vbz Chain A (length=256) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKEIPKEDLGYPWTKLKTNKLSTIYRGEYYKSPVTIKVFNNPKAESVGIV
RLTFNEEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRE
LLDRDKDLTMSVRSLLVLRAARGLYRLHHSGTLHGNISSSSFLVAGGYQV
KLAGFELSRFSSTAYVSPERLQDPFCKYDTKAEIYSFGIVLWEIATGKIP
FEGCDSEKIYELVAENKKQEPVGQDCPELLQEIINECRAHEPSNRPSADG
ILERLP
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6vbz Chain A Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6vbz Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.
Resolution2.192 Å
Binding residue
(original residue number in PDB)		E426 E430
Binding residue
(residue number reindexed from 1)		E228 E232
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) N318 S322 S323 G336
Catalytic site (residue number reindexed from 1) N136 S140 S141 G154
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6vbz, PDBe:6vbz, PDBj:6vbz
PDBsum6vbz
PubMed32561735
UniProtD3ZKP6

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