Structure of PDB 6v4s Chain A Binding Site BS01

Receptor Information
>6v4s Chain A (length=585) Species: 1385624 (Desulfofustis sp. PB-SRB1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EGRVQHFTGYIEDGRGIFYSLPDMKQGDIIYASMQNTGGNLDPLVGIMAE
EIDPAVSLGQVLEKALNDLISELTAVADRIFLGWDDDGGKGYSASLEFTI
PRDGTYHIFAGSTITNQRLDKFQPTYTTGSFQLILGLNAPQVISGEGEPE
GEVFASLASKPEAHVQELEIRLDKDTRYLTQHTRNLQPGDTFHALVEPIG
EAPLPRLRLTDSGGKPLAFGLIDQPGESVELNYTCDQDICELVVHVDGTD
GQKDSGEAVYRLLVGINSVFLESDLVTVGLAVDQIVGVDQRSENFSVVGT
LKLSWHDPKLGFSPDQCGCTVKSFEDASIRAVAGEINLPLPSFSFYNQQG
NRWSQNQVIFVTPDGRASYFERFTVTLQAPDFDFLAYPFDRQKFSIKVDL
AVPTNMFIFNEIERFQQVVGDQLGEEEWVVTSYSQEITEVPFERGSTNSR
FTTTLLVKRNLEYYILRIFVPLFLIISVSWVIFFLKDYGRQLEVASGNLL
VFVAFNFTISGDLPRLGYLTVLDRFMIVSFCLTAIVVLISVCQKRLGAVG
KQAVAAQIDTWVLVIYPLVYSLYIIWVYLRFFTDH
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6v4s Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6v4s Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel.
Resolution3.55 Å
Binding residue
(original residue number in PDB)		E347 P434
Binding residue
(residue number reindexed from 1)		E293 P380
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0007165 signal transduction
GO:0034220 monoatomic ion transmembrane transport
GO:0042391 regulation of membrane potential
Cellular Component
GO:0016020 membrane
GO:0043005 neuron projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6v4s, PDBe:6v4s, PDBj:6v4s
PDBsum6v4s
PubMed32482881
UniProtV4JF97

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