Structure of PDB 6v4c Chain A Binding Site BS01

Receptor Information
>6v4c Chain A (length=294) Species: 7176 (Culex quinquefasciatus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EWSPMDPEEVAFEEAKCMEDHFGNDFGLAEKWMKWSLAESDGKTACYVKC
LVEALGMYDKQAFQPNNIKQQYEAYKSDNGVDQTKGDAIANELGKIDAKD
GKCESIAKGFIQVNNANKGVLEKIYLLDSSVRDAIYKKNPQIKPKGISIF
RFCGKQFYQDGEAAYCNVRKHGFSDDPKFIKHSNCTTRGMRWMKKNGEMD
ESAILRGLHAVNENGKDDVVKKSLQNCKAKDESKARDYYKCIYDGLGEQL
FMKVLDYIEVRSENYSYRLREATSKYDANAMRSKVKALDSEAKC
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain6v4c Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6v4c ADP binding by the Culex quinquefasciatus mosquito D7 salivary protein enhances blood feeding on mammals.
Resolution1.97 Å
Binding residue
(original residue number in PDB)		E9 A12 R133 Y137 K144 P145 K146 N265 Y266 S267
Binding residue
(residue number reindexed from 1)		E8 A11 R132 Y136 K143 P144 K145 N264 Y265 S266
Annotation score4
Binding affinityMOAD: Kd=32.68nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0005549 odorant binding
GO:0090729 toxin activity
Biological Process
GO:0035821 modulation of process of another organism
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6v4c, PDBe:6v4c, PDBj:6v4c
PDBsum6v4c
PubMed32518308
UniProtA0A1S4K3K8|D7L1_CULQU Long form salivary protein D7L1 (Gene Name=D7L1)

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