Structure of PDB 6v2e Chain A Binding Site BS01

Receptor Information

>6v2e Chain A (length=555) Species: 9606,83333 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINA
ASGRQTVDEALKDAQTNAAAEFGGTVKNYETAVQFCWNHYKDQMDPIEKD
WCDWAMISRPYSTLRDCLEHFAERFDLGFPNPLAERIIFETHQIHFANCS
LVQPTFSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLC
WNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNY
TQCNV

Ligand information

>6v2e Chain B (length=16) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

DKDNVAPRRLIGPWGY

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6v2e Picomolar Affinity Antagonist and Sustained Signaling Agonist Peptide Ligands for the Adrenomedullin and Calcitonin Gene-Related Peptide Receptors.
Resolution	1.83 Å
Binding residue (original residue number in PDB)	Q154 R356 R1097 E1101 T2037 D2070 W2072 D2090 Y2091 F2092 Q2093 D2094 H2114 A2116 S2117 R2119 W2121 T2122
Binding residue (residue number reindexed from 1)	Q152 R354 R415 E419 T463 D496 W498 D516 Y517 F518 Q519 D520 H540 A542 S543 R545 W547 T548

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0015026	coreceptor activity
GO:0015144	carbohydrate transmembrane transporter activity

	Biological Process
GO:0006886	intracellular protein transport
GO:0007186	G protein-coupled receptor signaling pathway
GO:0008277	regulation of G protein-coupled receptor signaling pathway
GO:0008643	carbohydrate transport
GO:0055085	transmembrane transport

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:6v2e, PDBe:6v2e, PDBj:6v2e
PDBsum	6v2e
PubMed	32832875
UniProt	O60895\|RAMP2_HUMAN Receptor activity-modifying protein 2 (Gene Name=RAMP2); P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE); Q16602\|CALRL_HUMAN Calcitonin gene-related peptide type 1 receptor (Gene Name=CALCRL)

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