Structure of PDB 6v1q Chain A Binding Site BS01

Receptor Information
>6v1q Chain A (length=538) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTEKFDLATVYVSDAKYNRNIFFDTSPQAVKLYLLYNHWFMQTLVYVFII
INLALALFEDPAVVPLPIWATSTIETICLSAFTVRIIHYAKVIPKDKFWK
DPKNICIIIIVTLSFIDMVIYGALKATGHYGIRWSRVLRPLLLVNVTEGR
QLRRAFRSIRNALPQISYVFFLFMFSVLVFSLMALKLFGKRGLLTINGSP
YFTDYMDIVFDLYVLVTTANSPDVMMPAYNSSVYFTIFFILYIVINTYTF
MSFFLAVVYNNYKKYLKEEVRQLVKAKRIKMCRAFSLPSRFIRQMVHHRV
FVYAYDLIILVNAVFIGLDEENPVVSNAEWGFLALYMLEILLFWNWFDTI
IVVSALFGTIINSALKHSGGYTSRQVLDIVFILRVLRLIRVVDSIKRFRA
IINTLIKIGPTILTFGQLILVVYYIFAMVGMELFKGKIQFFEPNSTSPDR
EYCGNPLLKSTSFAKLNYCKNNFNDVISSFILLLELTVVNQWHVLTSGFT
AVTHVSARLFFVIFHIVVVIIIINIFVAFILEAFLVEY
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain6v1q Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6v1q Resting state structure of the hyperdepolarization activated two-pore channel 3.
Resolution3.11 Å
Binding residue
(original residue number in PDB)		T251 N624
Binding residue
(residue number reindexed from 1)		T218 N490
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001508 action potential
GO:0006811 monoatomic ion transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6v1q, PDBe:6v1q, PDBj:6v1q
PDBsum6v1q
PubMed31924746
UniProtC4IXV6

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