Structure of PDB 6v18 Chain A Binding Site BS01

Receptor Information
>6v18 Chain A (length=179) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRF
ASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELRE
PNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYL
PFLPSTEDVYDCRVEHWGLDEPLLKHWEF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6v18 The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		Q9 I31 A52 S53 F54 N62 V65 N69 R76
Binding residue
(residue number reindexed from 1)		Q8 I30 A51 S52 F53 N61 V64 N68 R75
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6v18, PDBe:6v18, PDBj:6v18
PDBsum6v18
PubMed33863750
UniProtP01903|DRA_HUMAN HLA class II histocompatibility antigen, DR alpha chain (Gene Name=HLA-DRA)

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