Structure of PDB 6v0t Chain A Binding Site BS01

Receptor Information

>6v0t Chain A (length=402) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TPPQVNSILKANEYSFKVPEFDGKNVSSVLGFDSNQLPANAPIEDRRSAA
TCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAV
ESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNIDVKEAL
INAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHV
ANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNEREVERLKLEHPKNEAKS
VVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPKFIPPNYYTPPYL
TAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMDQNAA
THLIRHAVGNNEFGAERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGA
YQ

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

6v0t Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6v0t Crystal structure of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase.
Resolution	2.1 Å
Binding residue (original residue number in PDB)	D73 G74
Binding residue (residue number reindexed from 1)	D64 G65
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.1.3.43: [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase.

Gene Ontology

	Molecular Function
GO:0004722	protein serine/threonine phosphatase activity
GO:0043169	cation binding

	Biological Process
GO:0006470	protein dephosphorylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:6v0t, PDBe:6v0t, PDBj:6v0t
PDBsum	6v0t
PubMed	32627744
UniProt	P35816\|PDP1_BOVIN [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (Gene Name=PDP1)

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