Structure of PDB 6uv3 Chain A Binding Site BS01

Receptor Information
>6uv3 Chain A (length=426) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHA
NFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYL
LPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQQVADDYGKCSRLKST
CIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGKTNLRRCTYLVLDE
ADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYTQ
INVGNLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKENKTIIFVE
TKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIATD
VASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGN
LKQARELIKVLEEANQAINPKLMQLV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6uv3 RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis.
Resolution1.597 Å
Binding residue
(original residue number in PDB)		P173 T174 R175 G201 G202 T222 G224 R225 D228 R250 F256 Q259 E347 T348 K349 H370 G371 R378 T396 V398 N418
Binding residue
(residue number reindexed from 1)		P126 T127 R128 G154 G155 T175 G177 R178 D181 R203 F209 Q212 E300 T301 K302 H323 G324 R331 T349 V351 N371
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6uv3, PDBe:6uv3, PDBj:6uv3
PDBsum6uv3
PubMed31851931
UniProtQ92841|DDX17_HUMAN Probable ATP-dependent RNA helicase DDX17 (Gene Name=DDX17)

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