Structure of PDB 6uv2 Chain A Binding Site BS01

Receptor Information
>6uv2 Chain A (length=431) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WDLSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVF
AFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGK
TLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQQVADDYGKCS
RLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGKTNLRRCTY
LVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFL
RDYTQINVGNLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKENKT
IIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPI
LIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTF
FTPGNLKQARELIKVLEEANQAINPKLMQLV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6uv2 RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis.
Resolution1.894 Å
Binding residue
(original residue number in PDB)		P173 T174 R175 G201 G202 T222 G224 R225 D228 R250 F256 Q259 E347 T348 K349 H370 G371 R378 T396 V398 N418
Binding residue
(residue number reindexed from 1)		P131 T132 R133 G159 G160 T180 G182 R183 D186 R208 F214 Q217 E305 T306 K307 H328 G329 R336 T354 V356 N376
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6uv2, PDBe:6uv2, PDBj:6uv2
PDBsum6uv2
PubMed31851931
UniProtQ92841|DDX17_HUMAN Probable ATP-dependent RNA helicase DDX17 (Gene Name=DDX17)

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