Structure of PDB 6uli Chain A Binding Site BS01
Receptor Information
>6uli Chain A (length=273) Species:
9606
(Homo sapiens) [
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SHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPW
VEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQRMYGC
DLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADKAAQITQRKWEAAR
EAEQRRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEATL
RCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPS
GEEQRYTCHVQHEGLPEPLTLRW
Ligand information
>6uli Chain C (length=9) Species:
9606
(Homo sapiens) [
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GADGVGKSA
Receptor-Ligand Complex Structure
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PDB
6uli
High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D.
Resolution
1.88 Å
Binding residue
(original residue number in PDB)
Y7 E63 K66 R69 Q70 T73 V76 S77 N80 Y84 Y99 T143 K146 W147 R156 Y159 W167 Y171
Binding residue
(residue number reindexed from 1)
Y6 E62 K65 R68 Q69 T72 V75 S76 N79 Y83 Y98 T142 K145 W146 R155 Y158 W166 Y170
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6uli
,
PDBe:6uli
,
PDBj:6uli
PDBsum
6uli
PubMed
32461371
UniProt
C1K0Y1
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