Structure of PDB 6ukn Chain A Binding Site BS01

Receptor Information
>6ukn Chain A (length=536) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVMESFLIVAMCCTCTML
TAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMY
ILGTIEIFLTYISPSAAIFQAETADGEAAALLNNMRVYGSCALALMAVVV
FVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFAPPDIPVCLLGNRTLA
NRNFDTCAKMQVVSNGTVTTALWRLFCNGSSLGATCDEYFAQNNVTEIQG
IPGVASGVFLDNLWSTYSDKGAFVEKKGVSSVPVSEESRPGGLPYVLTDI
MTYFTMLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIY
LSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTC
GAGLQSLTGAPRLLQAIARDGIIPFLQVFGHGKANGEPTWALLLTALICE
TGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKFYHW
TLSFLGMSLCLALMFICSWYYALFAMLIAGCIYKYI
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain6ukn Chain A Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ukn Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs.
Resolution3.65 Å
Binding residue
(original residue number in PDB)		N131 I132 Y216 P429 S430 T432 G433
Binding residue
(residue number reindexed from 1)		N15 I16 Y100 P313 S314 T316 G317
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015293 symporter activity
GO:0015377 chloride:monoatomic cation symporter activity
GO:0015379 potassium:chloride symporter activity
GO:0019901 protein kinase binding
GO:0022857 transmembrane transporter activity
GO:0046872 metal ion binding
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:0071333 cellular response to glucose stimulus
GO:0071805 potassium ion transmembrane transport
GO:1902476 chloride transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ukn, PDBe:6ukn, PDBj:6ukn
PDBsum6ukn
PubMed32286222
UniProtQ9WVL3|S12A7_MOUSE Solute carrier family 12 member 7 (Gene Name=Slc12a7)

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