Structure of PDB 6uj0 Chain A Binding Site BS01

Receptor Information
>6uj0 Chain A (length=367) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AMVDNLQGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFD
TERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIF
ESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQ
MCGAGLPVANGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGG
QSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPAFSDG
FWTGSQLACWSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMYE
CYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVS
EISGPFSTEDVASNCVP
Ligand information
Receptor-Ligand Complex Structure
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PDB6uj0 A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		S278 Q279 L280 C282
Binding residue
(residue number reindexed from 1)		S255 Q256 L257 C259
Enzymatic activity
Enzyme Commision number 3.4.23.45: memapsin 1.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6uj0, PDBe:6uj0, PDBj:6uj0
PDBsum6uj0
PubMed33544569
UniProtQ9Y5Z0|BACE2_HUMAN Beta-secretase 2 (Gene Name=BACE2)

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