Structure of PDB 6uah Chain A Binding Site BS01

Receptor Information

>6uah Chain A (length=265) Species: 522373 (Stenotrophomonas maltophilia K279a) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

APLPQLRAYTVDASWLQPMAPLQVADHTWQIGTEDLTALLVQTAEGAVLL
DGGMPQMAGHLLDNMKLRGVAPQDLRLILLSHAHADHAGPVAELKRRTGA
HVAANAETAVLLARGGSNDLHFGDGITYPPASADRIIMDGEVVTVGGIAF
TAHFMPGHTPGSTAWTWTDTRDGKPVRIAYADSLSAPGYQLKGNPRYPRL
IEDYKRSFATVRALPCDLLLTPHPGASNWNYAVGSKASAEALTCNAYADA
AEKKFDAQLARETAG

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

6uah Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6uah Crystal Structure of the Metallo-beta-Lactamase L1 from Stenotrophomonas maltophilia in the Complex with Hydrolyzed Meropenem
Resolution	1.98 Å
Binding residue (original residue number in PDB)	H105 H107 H181
Binding residue (residue number reindexed from 1)	H82 H84 H158
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	H105 H107 D109 H110 H181 Y212 H246
Catalytic site (residue number reindexed from 1)	H82 H84 D86 H87 H158 Y189 H223
Enzyme Commision number	3.5.2.6: beta-lactamase.

Gene Ontology

	Molecular Function
GO:0008270	zinc ion binding
GO:0008800	beta-lactamase activity

	Biological Process
GO:0017001	antibiotic catabolic process

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Molecular Function

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Biological Process

External links

PDB	RCSB:6uah, PDBe:6uah, PDBj:6uah
PDBsum	6uah
PubMed
UniProt	B2FTM1

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