Structure of PDB 6u8z Chain A Binding Site BS01

Receptor Information
>6u8z Chain A (length=568) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSP
EIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTK
RTLMRLHPNIKVMRHPDHVLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDN
EHRLTDVGSVFWHGKDYCNFVFKDWVIDRYSTPRMPWHDIASAVHGKAAR
DVARHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTELRYQVPGSVHANVQ
LLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVV
FNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGGGNALQAIMHFNYR
TMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSK
LLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQA
GRFARGLRLQCFRVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIY
DKVFRCLPNDEVHNLIQLRDFINKPVLAKEDPIRAEEELKKIRGFLVQFP
FYFLSEESLLPVPMEVWT
Ligand information
Ligand IDPO3
InChIInChI=1S/O3P/c1-4(2)3/q-3
InChIKeyAQSJGOWTSHOLKH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P-]([O-])=O
ACDLabs 10.04[O-][PH2-]([O-])=O
OpenEye OEToolkits 1.5.0[O-][P-](=O)[O-]
FormulaO3 P
NamePHOSPHITE ION
ChEMBL
DrugBank
ZINC
PDB chain6u8z Chain A Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6u8z Crystal structure of human PLD1 provides insight into activation by PI(4,5)P2and RhoA.
Resolution1.799 Å
Binding residue
(original residue number in PDB)		H464 K466 H896 K898
Binding residue
(residue number reindexed from 1)		H124 K126 H398 K400
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.4.4: phospholipase D.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004630 phospholipase D activity
Biological Process
GO:0006654 phosphatidic acid biosynthetic process
GO:0035556 intracellular signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6u8z, PDBe:6u8z, PDBj:6u8z
PDBsum6u8z
PubMed32198492
UniProtQ13393|PLD1_HUMAN Phospholipase D1 (Gene Name=PLD1)

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