Structure of PDB 6u8p Chain A Binding Site BS01

Receptor Information
>6u8p Chain A (length=291) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIA
VGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARK
GLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISR
FLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEY
NRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFP
VHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6u8p Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.
Resolution3.05 Å
Binding residue
(original residue number in PDB)		V657 P659 G824
Binding residue
(residue number reindexed from 1)		V95 P97 G262
Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6u8p, PDBe:6u8p, PDBj:6u8p
PDBsum6u8p
PubMed32620778
UniProtQ9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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