Structure of PDB 6u8i Chain A Binding Site BS01
Receptor Information
>6u8i Chain A (length=109) Species:
9606
(Homo sapiens) [
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SEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDM
STIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVF
EMRFAKMPD
Ligand information
>6u8i Chain B (length=12) Species:
32630
(synthetic construct) [
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WSWLCKKYNLIH
Receptor-Ligand Complex Structure
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PDB
6u8i
Cyclic peptides can engage a single binding pocket through highly divergent modes.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
W374 P375 F376 K378 L385 L387 H437 E438
Binding residue
(residue number reindexed from 1)
W24 P25 F26 K28 L35 L37 H87 E88
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6u8i
,
PDBe:6u8i
,
PDBj:6u8i
PDBsum
6u8i
PubMed
33046654
UniProt
O60885
|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)
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