Structure of PDB 6u7k Chain A Binding Site BS01

Receptor Information
>6u7k Chain A (length=1064) Species: 229032 (Porcine epidemic diarrhea virus CV777) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APAVVVLGGYLPSVHGIFLSVGITWDNDRVTVFADKIYHFYLKNAMQYVY
TPTYYMLNVTSAGIYYEPCTANCTGYAANVFATDSNGHIPEGFSFNNWFL
LSNDSTLLHGKVVSNQPLLVNCLLAIPKIYGLGQFFSFNHTMDGVCNGAA
VDRAPEALRFNINDTSVILAEGSIVLHTALGTNLSFVCSNSSDPHLATEV
PYYCFLKVDTYNSTVYKFLAVLPPTVREIVITKYGDVYVNGFGYLHLGLL
DAVTINFTGHGTDDDVSGFWTIASTNFVDALIEVQGTSIQRILYCDDPVS
QLKCSQVAFDLDDGFYPISSRNLLSHEQPISFVTLPSFNDHSFVNITVSA
AFGGLSSANLVASDTTINGFSSFCVDTRQFTITLFYNVTNSYGYVSKSQD
SNCPFTLQSVNDYLSFSKFCVSTSLLAGACTIDLFGYPAFGSGVKLTSLY
FQFTKGELITGTPKPLEGITDVSFMTLDVCTKYTIYGFKGEGIITLTNSS
ILAGVYYTSDSGQLLAFKNVTSGAVYSVTPCSFSEQAAYVNDDIVGVISS
LSNSTFNNTRELPGFFYHSNDGSNCTEPVLVYSNIGVCKSGSIGYVPSQY
GQVKIAPTVTGNISIPTNFSMSIRTEYLQLYNTPVSVDCATYVCNGNSRC
KQLLTQYTAACKTIESALQLSARLESVEVNSMLTISEEALQLATISSFNG
DGYNFTNVLGAKRSVIEDLLFNKVVTNGLGTVDEDYKRCSNGRSVADLVC
AQYYSGVMVLPGVVDAEKLHMYSASLIGGMALGGITAAAALPFSYAVQAR
LNYLALQTDVLQRNQQLLAESFNSAIGNITSAFESVKEAISQTSKGLNTV
AHALTKVQEVVNSQGSALNQLTVQLQHNFQAISSSIDDIYSRLDILSADV
QVDRLITGRLSALNAFVAQTLTKYTEVQASRKLAQQKVNECVKSQSQRYG
FCGGDGEHIFSLVQAAPQGLLFLHTVLVPGDFVNVLAIAGLCVNGEIALT
LREPGLVLFTHELQTYTATEYFVSSRRMFEPRKPTVSDFVQIESCVVTYV
NLTSDQLPDVIPDY
Ligand information
Ligand IDMAN
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-PQMKYFCFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-mannopyranose;
alpha-D-mannose;
D-mannose;
mannose
ChEMBLCHEMBL365590
DrugBank
ZINCZINC000003860903
PDB chain6u7k Chain D Residue 5 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6u7k The 3.1-Angstrom Cryo-electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion Conformation.
Resolution3.14 Å
Binding residue
(original residue number in PDB)		R311 E314 K399
Binding residue
(residue number reindexed from 1)		R153 E156 K233
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046813 receptor-mediated virion attachment to host cell
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0055036 virion membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6u7k, PDBe:6u7k, PDBj:6u7k
PDBsum6u7k
PubMed31534041
UniProtQ91AV1|SPIKE_PEDV7 Spike glycoprotein (Gene Name=S)

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