Structure of PDB 6u71 Chain A Binding Site BS01
Receptor Information
>6u71 Chain A (length=110) Species:
9606
(Homo sapiens) [
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SSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMD
LSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDV
FEFRYAKMPD
Ligand information
>6u71 Chain B (length=11) Species:
32630
(synthetic construct) [
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WWIIPKVKKGC
Receptor-Ligand Complex Structure
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PDB
6u71
Cyclic peptides can engage a single binding pocket through highly divergent modes.
Resolution
1.47 Å
Binding residue
(original residue number in PDB)
W370 P371 V376 L381 N429 H433 D434 V435
Binding residue
(residue number reindexed from 1)
W25 P26 V31 L36 N84 H88 D89 V90
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6u71
,
PDBe:6u71
,
PDBj:6u71
PDBsum
6u71
PubMed
33046654
UniProt
P25440
|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)
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