Structure of PDB 6u1x Chain A Binding Site BS01

Receptor Information
>6u1x Chain A (length=2059) Species: 11285 (Vesicular stomatitis Indiana virus strain San Juan) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NHADYNLNSPLISDDIDNLIRKFNSLPIPSMWDSKNWDGVLEMLTSCQAN
PISTSQMHKWMGSWLMSDNHDASQGYSFLHEVDKEAEITFDVVETFIRGW
GNKPIEYIKKERWTDSFKILAYLCQKFLDLHKLTLILNAVSEVELLNLAR
TFKGKVRRSSHGTNICRIRVPSLGPTFISEGWAYFKKLDILMDRNFLLMV
KDVIIGRMQTVLSMVCRIDNLFSEQDIFSLLNIYRIGDKIVERQGNFSYD
LIKMVEPICNLKLMKLARESRPLVPQFPHFENHIKTSVDEGAKIDRGIRF
LHDQIMSVKTVDLTLVIYGSFRHWGHPFIDYYTGLEKLHSQVTMKKDIDV
SYAKALASDLARIVLFQQFNDHKKWFVNGDLLPHDHPFKSHVKENTWPTA
AQVQDFGDKWHELPLIKCFEIPDLLDPSIIYSDKSHSMNRSEVLKHVRMN
PNTPIPSKKVLQTMLDTKATNWKEFLKEIDEKGLDDDDLIIGLKGKEREL
KLAGRFFSLMSWKLREYFVITEYLIKTHFVPMFKGLTMADDLTAVIKKML
DSSSGQGLKSYEAICIANHIDYEKWNNHQRKLSNGPVFRVMGQFLGYPSL
IERTHEFFEKSLIYYNGRPDLMRVHNNTLINSTSQRVCWQGQEGGLEGLR
QKGWTILNLLVIQREAKIRNTAVKVLAQGDNQVICTQYKTKKSRNVVELQ
GALNQMVSNNEKIMTAIKIGTGKLGLLINDDETMQSADYLNYGKIPIFRG
VIRGLETKRWSRVTCVTNDQIPTCANIMSSVSTNALTVAHFAENPINAMI
QYNYFGTFARLLLMMHDPALRQSLYEVQDKIPGLHSSTFKYAMLYLDPSI
GGVSGMSLSRFLIRAFPDPVTESLSFWRFIHVHARSEHLKEMSAVFGNPE
IAKFRITHIDKLVEDPTSLNIAMGMSPANLLKTEVKKCLIESRQTIRNQV
IKDATIYLYHEEDRLRSFLWSINPLFPRFLSEFKSGTFLGVADGLISLFQ
NSRTIRNSFKKKYHRELDDLIVRSEVSSLTHLGKLHLRRGSCKMWTCSAT
HADTLRYKSWGRTVIGTTVPHPLEMLGPQHRKETPCAPCNTSGFNYVSVH
CPDGIHDVFSSRGPLPAYLGSKTSESTSILQPWERESKVPLIKRATRLRD
AISWFVEPDSKLAMTILSNIHSLTGEEHGFKRTGSALHRFSTSRMSHGGF
ASQSTAALTRLMATTDTMRDLGDQNFDFLFQATLLYAQITTTVARDGWIT
SCTDHYHIACKSCLRPIEEITLDSSMDYTPPDVSHVLKTWRNGEIKQIYP
LEGNWKNLAPAEQSYQVGRCIGFLYGDLAYRKSTHAEDSSLFPLSIQGRI
RGRGFLKGLLDGLMRASCCQVIHRRSLAHLKRPANAVYGGLIYLIDKLSV
SPPFLSLTRSGPIRDELETIPHKIPTSYPTSNRDMGVIVRNYFKYQCRLI
EKGKYRSHYSQLWLFSDVLSIDFIGPFSISTTLLQILYKPFLSGKDKNEL
RELANLSSLLRSGEGWEDIHVKFFTKDILLCPEEIRHACKFGIAKMSYPP
WGRESRGTITTIPVYYTTTPYPKMLEMPPRIQNPLLSGIRLGQLPTGAHY
KIRSILHGMGIHYRDFLSCGDGSGGMTAALLRENVHSRGIFNSLLELSGS
VMRGASPEPPSALETLGGDKSRCVNGETCWEYPSDLCDPRTWDYFLRLKA
GLGLQIDLIVMDMEVRDSSTSLKIETNVRNYVHRILDEQGVLIYKTYGTY
ICESEKNAVTILGPMFKTVDLVQTEFSSSQTSEVYMVCKGLKKLIDEPNP
DWSSINESWKNLYAFQSSEQEFARAKKVSTYFTLTGIPSQFIPDPFVNIE
TMLQIFGVPTGVSHAAALKSSDRPADLLTISLFYMAIISYYNINHIRVGP
IPPNPPSDGIAQNVGIAITGISFWLSLMEKDIPLYQQCLAVIQQSFPIRW
EAVSVKGGYKQKWSTRGDGLPKDTRISDSLAPIGNWIRSLELVRNQVRLN
PFNEILFNQLCRTVDNHLKWSNLRRNTGMIEWINRRISKEDRSILMLKSD
LHEENSWRD
Ligand information
>6u1x Chain P (length=28) Species: 11285 (Vesicular stomatitis Indiana virus strain San Juan) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
TKPSYFQAEQVEGFIQDYADEEVDVVFT
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6u1x Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		N704 Q739 N743 Y1375 R1419 N1430 A1431 Y1433 Y1438 E1496 K1497 G1498 Y1533 P1535 P1909 T1910 G1911 E1979 D1981 F2052 L2097 K2098 S2099 L2101
Binding residue
(residue number reindexed from 1)		N670 Q705 N709 Y1330 R1374 N1385 A1386 Y1388 Y1393 E1451 K1452 G1453 Y1488 P1490 P1859 T1860 G1861 E1929 D1931 F2002 L2047 K2048 S2049 L2051
Enzymatic activity
Enzyme Commision number 2.1.1.375: NNS virus cap methyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.88: GDP polyribonucleotidyltransferase.
3.6.1.-
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006139 nucleobase-containing compound metabolic process
GO:0006370 7-methylguanosine mRNA capping
GO:0019083 viral transcription
GO:0032259 methylation
GO:0039689 negative stranded viral RNA replication
GO:0106005 RNA 5'-cap (guanine-N7)-methylation
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6u1x, PDBe:6u1x, PDBj:6u1x
PDBsum6u1x
PubMed31914397
UniProtP03523|L_VSIVA RNA-directed RNA polymerase L (Gene Name=L)

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