Structure of PDB 6tw1 Chain A Binding Site BS01

Receptor Information
>6tw1 Chain A (length=703) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MENFVRTNFNPMILERAEKTMKEYGENPQNEGNKFAAISTHMEVCFMYSD
FHFIDLEGNTIVKENMLKHRFEIIEGQERNIAWTIVNSICNMTENSKPRF
LPDLYDYKTNKFIEIGVTRRKVEDYYYEKASKLKGENVYIHIFSFDGEEM
ATDDEYILDEESRARIKTRLFVLRQELATAGLWDSFRQSEEEEFSYPPTF
QRLANQSLPPSFKDYHQFKAYVSSFKANGNIEAKLGAMSEKVNAQIESFD
PRTIRELELPEGKFCTQRSKFLLMDAMKLSVLNPAHEGEGIPMKDAKACL
DTFWGWKKATIIKKHEKGVNTNYLMIWEQLLESIKEMEGKFLNLKKTNHL
KWGLGEGQAPEKMDFEDCKEVPDLFQYKSEPPEKRKLASWIQSEFNKASE
LTNSNWIEFDELGNDVAPIEHIASRRRNFFTAEVSQCRASEYIMKAVYIN
TALLNSSCTAMEEYQVIPIITKCRDTSGQRRTNLYGFIIKGRSHLRNDTD
VVNFISLEFSLTDPRNEIHKWEKYCVLEIGDMEIRTSISTIMKPVYLYVR
TNGTSKIKMKWGMEMRRCLLQSLQQVESMIEAESAVKEKDMTEPFFRNRE
NDWPIGESPQGIEKGTIGKVCRVLLAKSVFNSIYASAQLEGFSAESRKLL
LLIQAFRDNLDPGTFDLKGLYEAIEECIINDPWVLLNASWFNSFLKAVQL
SMG
Ligand information
>6tw1 Chain V (length=33) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aguaguaacaagagcaauguguccgucucugcu
.<<....>>........................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6tw1 A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Resolution2.7 Å
Binding residue
(original residue number in PDB)
R279 E300 G301 I302 H326 K328 F352 G366 G368 Q369 A370 P371 K373 Y388 K389 S390 P392 P393 V458 Y459 N466 S467 T470 R485 R491 R503 H505 R507 N508 V512 N514 K534 R561 T562 N563 G564 K569 R577
Binding residue
(residue number reindexed from 1)
R268 E289 G290 I291 H315 K317 F341 G355 G357 Q358 A359 P360 K362 Y377 K378 S379 P381 P382 V447 Y448 N455 S456 T459 R474 R480 R492 H494 R496 N497 V501 N503 K523 R550 T551 N552 G553 K558 R566
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:6tw1, PDBe:6tw1, PDBj:6tw1
PDBsum6tw1
PubMed32304664
UniProtH6QM92

[Back to BioLiP]