Structure of PDB 6tuo Chain A Binding Site BS01

Receptor Information

>6tuo Chain A (length=405) Species: 224325 (Archaeoglobus fulgidus DSM 4304) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GLTYRIGNGASVPISNTGELIKGLRNYGPYEVPSLKYNQIALIHNNQFSS
LINQLKSQISSKIDEVWHIHNINISEFIYDSPHFDSIKSQVDNAIDTGVD
GIMLVLPEYNTPLYYKLKSYLINSIPSQFMRYDILSNRNLTFYVDNLLVQ
FVSKLGGKPWILNVDPEKGSDIIIGTGATRIDNVNLFCFAMVFKKDGTML
WNEISPIVTSSEYLTYLKSTIKKVVYGFKKSNPDWDVEKLTLHVSGKRPK
MKDGETKILKETVEELKKQEMVSRDVKYAILHLNETHPFWVMHPYEGTKV
KLSSKRYLLTLLQPYLMVTPIKPLSVEIVSDNWTSEEYYHNVHEILDEIY
YLSKMNWRGFRSRNLPVTVNYPKLVAGIIANVNRYGGYPINPEGNRSLQT
NPWFL

Ligand information

>6tuo Chain R (length=14) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

attgtacgtacaat

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6tuo Crystal structure of Archaeoglobus fulgidus Argonaute protein with cognate DNA oligoduplex 5'-pATTGTACGTACAAT
Resolution	1.8 Å
Binding residue (original residue number in PDB)	N119 T120 Y123 K127 Q137 F138 M139 R140 R147 Y152 N155 Q159 K163 P330 Y331 L332 R380 L427
Binding residue (residue number reindexed from 1)	N110 T111 Y114 K118 Q128 F129 M130 R131 R138 Y143 N146 Q150 K154 P314 Y315 L316 R358 L405

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:6tuo, PDBe:6tuo, PDBj:6tuo
PDBsum	6tuo
PubMed
UniProt	O28951\|PIWI_ARCFU Piwi protein (Gene Name=AF_1318)

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