Structure of PDB 6tqz Chain A Binding Site BS01

Receptor Information

>6tqz Chain A (length=285) Species: 1392 (Bacillus anthracis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MRAVNWNKKEDDFSLMFWKQNIAQFWTEEEIAVSSDKNTWVQLSKEEQIA
YKRVLGGLTLGDTKQGGEGMPLVLVHLENLQAKSVLAFMGAMEEVHAKSY
SHIFTTLATEEEIDEIFDWVDTHPLLEKKAGIITSYYRRLLKPEVTKKEL
YMAMVASVFLESYLFYSGFFYPLYLAGQGKLTASGEIINLIIRDESIHGV
FVGILAQQIFAELSAEDQQEVQKETQELLMELYEIEMAYTEEIYTSIGLV
EDVNRFVRYNANKGLMNLGLEPKFEEINPIVLNGL

Ligand information

InChI=1S/Fe/q+2

CWYNVVGOOAEACU-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Fe+2]
CACTVS 3.341	[Fe++]

Formula

Name

FE (II) ION

PDB chain

6tqz Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6tqz The Bacillus anthracis class Ib ribonucleotide reductase subunit NrdF intrinsically selects manganese over iron.
Resolution	2.09933 Å
Binding residue (original residue number in PDB)	E93 E161 E195 H198
Binding residue (residue number reindexed from 1)	E93 E161 E195 H198
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.17.4.1: ribonucleoside-diphosphate reductase.

Gene Ontology

	Molecular Function
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

	Biological Process
GO:0009263	deoxyribonucleotide biosynthetic process

	Cellular Component
GO:0005971	ribonucleoside-diphosphate reductase complex
GO:0016020	membrane

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External links

PDB	RCSB:6tqz, PDBe:6tqz, PDBj:6tqz
PDBsum	6tqz
PubMed	32296998
UniProt	Q81TB4

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