Structure of PDB 6t7f Chain A Binding Site BS01

Receptor Information
>6t7f Chain A (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDMCMICFTEALSAAPAIQLDCSHIFHLQCCRRVLENRWLGPRITFGFIS
CPICKNKINHIVLKDLLDPIKELYEDVRRKALMRLEYEGLHKSEAITTPG
VRFYNDPAGYAMNRYAYYVCYKCRKAYFGGEARCDAEAGRGDDYDPRELI
CGACSDVSRAQMCPKHGTDFLEYKCRYCCSVAVFFCFGTTHFCNACHDDF
QRMTSIPKEELPHCPAGPKGKQLEGTECPLHVVHPPTGEEFALGCGVCRN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6t7f Chain A Residue 4701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6t7f Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity.
Resolution2.58 Å
Binding residue
(original residue number in PDB)		C4390 C4393 H4413 C4416
Binding residue
(residue number reindexed from 1)		C4 C7 H27 C30
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.33: RCR-type E3 ubiquitin transferase.
External links
PDB RCSB:6t7f, PDBe:6t7f, PDBj:6t7f
PDBsum6t7f
PubMed32747811
UniProtO75592|MYCB2_HUMAN E3 ubiquitin-protein ligase MYCBP2 (Gene Name=MYCBP2)

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