Structure of PDB 6t2f Chain A Binding Site BS01

Receptor Information
>6t2f Chain A (length=85) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETLVRPKPELLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHI
VYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV
Ligand information
>6t2f Chain B (length=14) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
LTFDQYWAQLDSAA
Receptor-Ligand Complex Structure
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PDB6t2f Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions.
Resolution2.09 Å
Binding residue
(original residue number in PDB)		L54 L57 G58 I61 Q72 H73 V93 H96 Y100
Binding residue
(residue number reindexed from 1)		L30 L33 G34 I37 Q48 H49 V69 H72 Y76
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:6t2f, PDBe:6t2f, PDBj:6t2f
PDBsum6t2f
PubMed31944488
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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