Structure of PDB 6t0w Chain A Binding Site BS01

Receptor Information
>6t0w Chain A (length=521) Species: 11520 (Influenza B virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEKGIDFKLGQTISRLRDISVPAGFSNFEGMRSYIDNIDPKGAIERNLAR
MSPLVSVTPKKLTWEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMT
EGKSKKPKTLAKECLEKYSTLRDQTDPILIMKSEKANENFLWKLWRDCVN
TISNEEMSNELQKTNYAKWATGDGLTYQKIMKEVAIDDETMCQEEPKIPN
KCRVAAWVQTEMNLLSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNE
INYCKASTVMMKYVLFHTSLLNESNASMGKYKVIPITNRVVNEKGESFDM
LYGLAVKGQSHLRGDTDVVTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLF
VSGREKSVYLYCRVNGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQ
GYDMTKACFKGDRVNSPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYV
FGNAQLEGFSAESRRLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPW
VIQSAYWFNEWLGFEKEGSKV
Ligand information
>6t0w Chain V (length=25) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aguaguaacaagaggccucucugcu
.<<....>>.<<<<..>>>>.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6t0w A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Resolution3.18 Å
Binding residue
(original residue number in PDB)		S299 K300 K330 G367 G369 L370 T371 P391 K392 I393 R417 D420 L460 T463 E468 R484 H506 R508 D512 V513 T515 V559 N560 G561 R574
Binding residue
(residue number reindexed from 1)		S104 K105 K135 G172 G174 L175 T176 P196 K197 I198 R222 D225 L265 T268 E273 R289 H311 R313 D317 V318 T320 V364 N365 G366 R379
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6t0w, PDBe:6t0w, PDBj:6t0w
PDBsum6t0w
PubMed32304664
UniProtQ5V8Z9

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