BioLiP

Receptor Information

>6t0v Chain A (length=705) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MENFVRTNFNPMILERAEKTMKEYGENPQNEGNKFAAISTHMEVCFMYSD
FHFIDLEGNTIVKENNAMLKHRFEIIEGQERNIAWTIVNSICNMTENSKP
RFLPDLYDYKTNKFIEIGVTRRKVEDYYYEKASKLKGENVYIHIFSFDGE
EMATDDEYILDEESRARIKTRLFVLRQELATAGLWDSFRQSEEEEFSYPP
TFQRLANQSLPPSFKDYHQFKAYVSSFKANGNIEAKLGAMSEKVNAQIES
FDPRTIRELELPEGKFCTQRSKFLLMDAMKLSVLNPAHEGEGIPMKDAKA
CLDTFWGWKKATIIKKHEKGVNTNYLMIWEQLLESIKEMEGKFLNLKKTN
HLKWGLGEGQAPEKMDFEDCKEVPDLFQYKSEPPEKRKLASWIQSEFNKA
SELTNSNWIEFDELGNDVAPIEHIASRRRNFFTAEVSQCRASEYIMKAVY
INTALLNSSCTAMEEYQVIPIITKCRDTSGQRRTNLYGFIIKGRSHLRND
TDVVNFISLEFSLTDPRNEIHKWEKYCVLEIGDMEIRTSISTIMKPVYLY
VRTNGTSKIKMKWGMEMRRCLLQSLQQVESMIEAESAVKEKDMTEPFFRN
RENDWPIGESPQGIEKGTIGKVCRVLLAKSVFNSIYASAQLEGFSAESRK
LLLLIQAFRDNLDPGTFDLKGLYEAIEECIINDPWVLLNASWFNSFLKAV
QLSMG

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6t0v A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Resolution	3.02 Å
Binding residue (original residue number in PDB)	H326 K328 W363 G366 G368 Q369 A370 P371 K373 Y388 K389 S390 P392 P393 R503 H505 R507 D511 V512 N514 K534 R561 T562 N563 G564 N691
Binding residue (residue number reindexed from 1)	H317 K319 W354 G357 G359 Q360 A361 P362 K364 Y379 K380 S381 P383 P384 R494 H496 R498 D502 V503 N505 K525 R552 T553 N554 G555 N682

Enzyme Commision number

	Molecular Function
GO:0003723	RNA binding
GO:0046872	metal ion binding

	Biological Process
GO:0039694	viral RNA genome replication
GO:0075523	viral translational frameshifting

PDB	RCSB:6t0v, PDBe:6t0v, PDBj:6t0v
PDBsum	6t0v
PubMed	32304664
UniProt	H6QM92

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Structure of PDB 6t0v Chain A Binding Site BS01