Structure of PDB 6t0s Chain A Binding Site BS01

Receptor Information
>6t0s Chain A (length=708) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MENFVRTNFNPMILERAEKTMKEYGENPQNEGNKFAAISTHMEVCFMYSD
FHFIDLEGNTIVKENDDMLKHRFEIIEGQERNIAWTIVNSICNMTENSKP
RFLPDLYDYKTNKFIEIGVTRRKVEDYYYEAASKLKGENVYIHIFSFDGE
EMATDDEYILDEESRARIKTRLFVLRQELATAGLWDSFRQSEKTLEEEFS
YPPTFQRLANQSLPPSFKDYHQFKAYVSSFKANGNIEAKLGAMSEKVNAQ
IESFDPRTIRELELPEGKFCTQRSKFLLMDAMKLSVLNPAHEGEGIPMKD
AKACLDTFWGWKKATIIKKHEKGVNTNYLMIWEQLLESIKEMEGKFLNLK
KTNHLKWGLGEGQAPEKMDFEDCKEVPDLFQYKSEPPEKRKLASWIQSEF
NKASELTNSNWIEFDELGNDVAPIEHIASRRRNFFTAEVSQCRASEYIMK
AVYINTALLNSSCTAMEEYQVIPIITKCRDTSGQRRTNLYGFIIKGRSHL
RNDTDVVNFISLEFSLTDPRNEIHKWEKYCVLEIGDMEIRTSISTIMKPV
YLYVRTNGTSKIKMKWGMEMRRCLLQSLQQVESMIEAESAVKEKDMTEPF
FRNRENDWPIGESPQGIEKGTIGKVCRVLLAKSVFNSIYASAQLEGFSAE
SRKLLLLIQAFRDNLDPGTFDLKGLYEAIEECIINDPWVLLNASWFNSFL
KAVQLSMG
Ligand information
>6t0s Chain V (length=33) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
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PDB6t0s A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Resolution3.04 Å
Binding residue
(original residue number in PDB)
R279 G301 I302 H326 K328 F352 G366 G368 Q369 A370 P371 K373 Y388 K389 S390 P392 P393 E419 V458 Y459 T462 N466 S467 T470 Q476 K483 R485 R503 H505 R507 D511 V512 N514 K534 R561 T562 N563 G564 K569 R577
Binding residue
(residue number reindexed from 1)
R273 G295 I296 H320 K322 F346 G360 G362 Q363 A364 P365 K367 Y382 K383 S384 P386 P387 E413 V452 Y453 T456 N460 S461 T464 Q470 K477 R479 R497 H499 R501 D505 V506 N508 K528 R555 T556 N557 G558 K563 R571
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:6t0s, PDBe:6t0s, PDBj:6t0s
PDBsum6t0s
PubMed32304664
UniProtH6QM92

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