Structure of PDB 6t0r Chain A Binding Site BS01

Receptor Information
>6t0r Chain A (length=701) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MENFVRTNFNPMILERAEKTMKEYGENPQNEGNKFAAISTHMEVCFMYSD
FHFIDLEGNTIVKMLKHRFEIIEGQERNIAWTIVNSICNMTENSKPRFLP
DLYDYKTNKFIEIGVTRRKVEDYYYEKASKLKGENVYIHIFSFDGEEMAT
DDEYILDEESRARIKTRLFVLRQELATAGLWDSFRQSEEEEFSYPPTFQR
LANQSLPPSFKDYHQFKAYVSSFKANGNIEAKLGAMSEKVNAQIESFDPR
TIRELELPEGKFCTQRSKFLLMDAMKLSVLNPAHEGEGIPMKDAKACLDT
FWGWKKATIIKKHEKGVNTNYLMIWEQLLESIKEMEGKFLNLKKTNHLKW
GLGEGQAPEKMDFEDCKEVPDLFQYKSEPPEKRKLASWIQSEFNKASELT
NSNWIEFDELGNDVAPIEHIASRRRNFFTAEVSQCRASEYIMKAVYINTA
LLNSSCTAMEEYQVIPIITKCRDTSGQRRTNLYGFIIKGRSHLRNDTDVV
NFISLEFSLTDPRNEIHKWEKYCVLEIGDMEIRTSISTIMKPVYLYVRTN
GTSKIKMKWGMEMRRCLLQSLQQVESMIEAESAVKEKDMTEPFFRNREND
WPIGESPQGIEKGTIGKVCRVLLAKSVFNSIYASAQLEGFSAESRKLLLL
IQAFRDNLDPGTFDLKGLYEAIEECIINDPWVLLNASWFNSFLKAVQLSM
G
Ligand information
>6t0r Chain V (length=20) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aguaguaacaagagucugcu
.<<....>>...........
Receptor-Ligand Complex Structure
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PDB6t0r A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Resolution2.82 Å
Binding residue
(original residue number in PDB)
E300 G301 I302 H326 K328 F352 G366 G368 Q369 A370 P371 E372 K373 Y388 S390 P392 P393 E419 Y459 T462 N466 S467 T470 Q476 K483 R485 R503 H505 R507 N508 D511 V512 N514 K534 R561 T562 N563 G564 K569 R577
Binding residue
(residue number reindexed from 1)
E287 G288 I289 H313 K315 F339 G353 G355 Q356 A357 P358 E359 K360 Y375 S377 P379 P380 E406 Y446 T449 N453 S454 T457 Q463 K470 R472 R490 H492 R494 N495 D498 V499 N501 K521 R548 T549 N550 G551 K556 R564
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:6t0r, PDBe:6t0r, PDBj:6t0r
PDBsum6t0r
PubMed32304664
UniProtH6QM92

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