Structure of PDB 6t0o Chain A Binding Site BS01

Receptor Information
>6t0o Chain A (length=164) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRS
ARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVF
KIDWICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFP
PDESIDLYQVIHKM
Ligand information
Ligand IDM6N
InChIInChI=1S/C8H7N3O/c1-5-10-7-4-9-3-2-6(7)8(12)11-5/h2-4H,1H3,(H,10,11,12)
InChIKeyZZGGQKRBGZEHKC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385
OpenEye OEToolkits 2.0.7		CC1=Nc2cnccc2C(=O)N1
FormulaC8 H7 N3 O
Name2-methyl-3~{H}-pyrido[3,4-d]pyrimidin-4-one
ChEMBL
DrugBank
ZINCZINC000034099990
PDB chain6t0o Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6t0o Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments.
Resolution1.71 Å
Binding residue
(original residue number in PDB)		K361 S362 N363 N367 W377 S378 W428 P431
Binding residue
(residue number reindexed from 1)		K18 S19 N20 N24 W34 S35 W85 P88
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:6t0o, PDBe:6t0o, PDBj:6t0o
PDBsum6t0o
PubMed32101404
UniProtQ96MU7|YTDC1_HUMAN YTH domain-containing protein 1 (Gene Name=YTHDC1)

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