Structure of PDB 6t09 Chain A Binding Site BS01

Receptor Information
>6t09 Chain A (length=161) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRS
ARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPSAKMLGGVFKID
WICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFPPDE
SIDLYQVIHKM
Ligand information
Ligand IDM4T
InChIInChI=1S/C7H8N2O/c1-6(10)9-7-3-2-4-8-5-7/h2-5H,1H3,(H,9,10)
InChIKeyJVYIBLHBCPSTKF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385
OpenEye OEToolkits 2.0.7		CC(=O)Nc1cccnc1
FormulaC7 H8 N2 O
Name~{N}-pyridin-3-ylethanamide
ChEMBLCHEMBL12056
DrugBank
ZINCZINC000000152540
PDB chain6t09 Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6t09 Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		W377 S378 L380 W428 L439
Binding residue
(residue number reindexed from 1)		W34 S35 L37 W85 L93
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:6t09, PDBe:6t09, PDBj:6t09
PDBsum6t09
PubMed32101404
UniProtQ96MU7|YTDC1_HUMAN YTH domain-containing protein 1 (Gene Name=YTHDC1)

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