Structure of PDB 6szi Chain A Binding Site BS01

Receptor Information

>6szi Chain A (length=1276) Species: 1245 (Leuconostoc mesenteroides)

LSDPITGGHYENHNGYFVYIDASGKQVTGLQNIDGNLQYFDDNGYQVKGS
FRDVNGKHIYFDSVTGKASSNVDIVNGKAQGYDAQGNQLKKSYVADSSGQ
TYYFDGNGQPLIGLQTIDGNLQYFNQQGVQIKGGFQDVNNKRIYFAPNTG
NAVANTEIINGKLQGRDANGNQVKNAFSKDVAGNTFYFDANGVMLTGLQT
ISGKTYYLDEQGHLRKNYAGTFNNQFMYFDADTGAGKTAIEYQFDQGLVS
QSNENTPHNAAKSYDKSSFENVDGYLTADTWYRPTDILKNGDTWTASTET
DMRPLLMTWWPDKQTQANYLNFMSSKGLGITTTYTAATSQKTLNDAAFVI
QTAIEQQISLKKSTEWLRDAIDSFVKTQANWNKQTEDEAFDGLQWLQGGF
LAYQDDSHRTPNTDSGNNRKLGRQPINIDGSKDTTDGKGSEFLLANDIDN
SNPIVQAEQLNWLHYLMNFGSITGNNDNANFDGIRVDAVDNVDADLLKIA
GDYFKALYGTDKSDANANKHLSILEDWNGKDPQYVNQQGNAQLTMDYTVT
SQFGNSLTHGANNRSNMWYFLDTGYYLNGDLNKKIVDKNRPNSGTLVNRI
ANSGDTKVIPNYSFVRAHDYDAQDPIRKAMIDHGIIKNMQDTFTFDQLAQ
GMEFYYKDQENPSGFKKYNDYNLPSAYAMLLTNKDTVPRVYYGDMYLEGG
QYMEKGTIYNPVISALLKARIKYVSGGQTMATDSSGKDLKDGETDLLTSV
RFGKGIMTSDQTTTQDNSQDYKNQGIGVIVGNNPDLKLNNDKTITLHMGK
AHKNQLYRALVLSNDSGIDVYDSDDKAPTLRTNDNGDLIFHKTNTFVKQD
GTIINYEMKGSLNALISGYLGVWVPVGASDSQDARTVATESSSSNDGSVF
HSNAALDSNVIYEGFSNFQAMPTSPEQSTNVVIATKANLFKELGITSFEL
APQYRSSGDTNYGGMSFLDSFLNNGYAFTDRYDLGFNKADGNPNPTKYGT
DQDLRNAIEALHKNGMQAIADWVPDQIYALPGKEVVTATRVDERGNQLKD
TDFVNLLYVANTKSSGVDYQAKYGGEFLDKLREEYPSLFKQNQVSTGQPI
DASTKIKQWSAKYMNGTNILHRGAYYVLKDWATNQYFNIAKTNEVFLPLQ
LQNKDAQTGFISDASGVKYYSISGYQAKDTFIEDGNGNWYYFDKDGYMVR
SQQGENPIRTVETSVNTRNGNYYFMPNGVELRKGFGTDNSGNVYYFDDQG
KMVRDKYINDDANNFYHLNVDGTMSR

Ligand information

• Ligand ID: GLC
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
• InChIKey: WQZGKKKJIJFFOK-DVKNGEFBSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(C(O1)O)O)O)O)O
  OpenEye OEToolkits 1.5.0: C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
  CACTVS 3.341: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  CACTVS 3.341: OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)CO
• Formula: C6 H12 O6
• Name: alpha-D-glucopyranose;
  alpha-D-glucose;
  D-glucose;
  glucose
• ChEMBL: CHEMBL423707
• ZINC: ZINC000003861213
• PDB chain: 6szi Chain C Residue 1

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6szi A specific oligosaccharide-binding site in the alternansucrase catalytic domain mediates alternan elongation.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): Q700 N703 S713
• Binding residue (residue number reindexed from 1): Q552 N555 S565
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.4.1.5: dextransucrase.

Gene Ontology

Molecular Function

• GO:0046527 glucosyltransferase activity

Biological Process

• GO:0009250 glucan biosynthetic process

External links

• PDB: RCSB:6szi, PDBe:6szi, PDBj:6szi
• PDBsum: 6szi
• PubMed: 32409580
• UniProt: Q9RE05