Structure of PDB 6sz7 Chain A Binding Site BS01

Receptor Information
>6sz7 Chain A (length=163) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRS
ARSVILIFSVRESGKFQGFARLSSESHHGSPIHWVLPAGMSAKMLGGVFK
IDWICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFPP
DESIDLYQVIHKM
Ligand information
Ligand IDM1Q
InChIInChI=1S/C8H10N2O2/c11-7-5-3-1-2-4-6(5)9-8(12)10-7/h5H,1-4H2,(H,10,11,12)/t5-/m0/s1
InChIKeySGSOSBGVUZKQTR-YFKPBYRVSA-N
SMILES
SoftwareSMILES
CACTVS 3.385O=C1NC(=O)[C@H]2CCCCC2=N1
CACTVS 3.385O=C1NC(=O)[CH]2CCCCC2=N1
OpenEye OEToolkits 2.0.7C1CCC2=NC(=O)NC(=O)C2C1
FormulaC8 H10 N2 O2
Name5,6,7,8-tetrahydro-4~{a}~{H}-quinazoline-2,4-dione
ChEMBL
DrugBank
ZINC
PDB chain6sz7 Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6sz7 Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments.
Resolution2.31 Å
Binding residue
(original residue number in PDB)		N367 W377 S378 T379 W428 P431 M434
Binding residue
(residue number reindexed from 1)		N24 W34 S35 T36 W84 P87 M90
Annotation score1
Binding affinityMOAD: ic50=1615uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:6sz7, PDBe:6sz7, PDBj:6sz7
PDBsum6sz7
PubMed32101404
UniProtA0A2K6KCS5

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