Structure of PDB 6sxo Chain A Binding Site BS01

Receptor Information
>6sxo Chain A (length=375) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMI
MEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLV
KIDLGVHVDGFIANVAHTFVVDVAQGTQVTGRKADVIKAAHLCAEAALRL
VKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPT
DQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRDPSKQYG
LKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFN
VLYEKEGEFVAQFKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKA
LLQSSASRKTQKKKKKKASKTAENA
Ligand information
>6sxo Chain L5 (length=268) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaaaagaacuuugaagagagaguucaagagggcguucaaacgagaacu
uugaaucggguucagauccccgaaucuuggaaagcgucgcgguuccggcg
gcguaagggcugggucggucgggcuggggcgcgaagcggggcugggcgcg
cgccgcggcuggacgaggcggcgacucuggacgcgagccgggcccuuccc
guggaucgccccagcugcggcgggcgucgcgcggcgccucgccucggccg
gcgccuagcagccgacuu
..........<<<......>>>..............<<<<<<.......>
>>>>><<<<<........>>>>>..........<<<<<<<.......>>>
>>>><<<<<<<<..<<<<<<<.<<<<<<<<<....<<<<<...<<<<.<<
.<<<<<<.<<<<<............>>>>>.>>>>.>>>>.>>>>..>>>
>>....>>>>>>>>>...<<<<<<<.<<<..>>>.>>>>.>>>.>>>>>>
>.......>>>>>..>>>
Receptor-Ligand Complex Structure
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PDB6sxo MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		K22 F64 K65 K66 K215 Q254 Y255 G256 L257 K258 R263 F266 S267 R271 R364 Q367 K370 K373 K376
Binding residue
(residue number reindexed from 1)		K16 F58 K59 K60 K209 Q248 Y249 G250 L251 K252 R257 F260 S261 R265 R358 Q361 K364 K367 K370
Enzymatic activity
Catalytic site (original residue number in PDB) D109 N120 H188 D196 D227 K320
Catalytic site (residue number reindexed from 1) D103 N114 H182 D190 D221 K314
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006364 rRNA processing
GO:0006417 regulation of translation
GO:0043066 negative regulation of apoptotic process
GO:0045597 positive regulation of cell differentiation
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0035578 azurophil granule lumen
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6sxo, PDBe:6sxo, PDBj:6sxo
PDBsum6sxo
PubMed32034140
UniProtQ9UQ80|PA2G4_HUMAN Proliferation-associated protein 2G4 (Gene Name=PA2G4)

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