Structure of PDB 6so5 Chain A Binding Site BS01

Receptor Information
>6so5 Chain A (length=313) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEPTLSNIIEQRSLKWIFVGGKGGVGKTTCSCSLAVQLSKGRESVLIIST
DPAHNISDAFDQKFSKVPTKVKGYDNLFAMEIDPSLGVAELPDEFFEEDN
MLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHT
LRLLNFPTIVERGLGRLMQIKNQISPFISQMCNADQLASKLEETLPVIRS
VSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKIDTHNIIVNQLV
FPDPEKPCKMCEARHKIQAKYLDQMEDLYEDFHIVKLPLLPHEVRGADKV
NTFSALLLEPYKP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6so5 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6so5 Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		C289 C292
Binding residue
(residue number reindexed from 1)		C258 C261
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.-.-
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015105 arsenite transmembrane transporter activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0032977 membrane insertase activity
GO:0046872 metal ion binding
Biological Process
GO:0015700 arsenite transport
GO:0045048 protein insertion into ER membrane
GO:0071816 tail-anchored membrane protein insertion into ER membrane
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0043529 GET complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6so5, PDBe:6so5, PDBj:6so5
PDBsum6so5
PubMed32910895
UniProtO43681|GET3_HUMAN ATPase GET3 (Gene Name=GET3)

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