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Receptor Information

>6sl3 Chain A (length=618) Species: 5759 (Entamoeba histolytica) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MADSELVAQWEKVQIKTFTKWVNMHLAKKGRKINDVTTDFKNGVELCALL
EIIGETTIKCVTNPKMRIQMTENLDKALRFIQSRDVKLTGIGPTDIVDGN
VKLTLGLVWTLILRFAISELSAEGLSAKQGLLLWCQKKCEPYPVKVENFS
ESFKDGKVFCALIHRHRPDLLDWETVGEDDRANLEKAFDVAEKELGIPKL
LDVDDIVNMPRPDERSVMTYVAALYKVFSSNDQVEKAGKRAGNFLDLLRA
TEGMVHDYEQRAQALKENIEAAINKMNGVEPSDEYHQVKEQINETKNYRK
GDKRAFIKEQGDLATLFGQINSKLRGMKRPVYVAPEGLDPKSLEGYIANI
SEAERALRSKLNTAMRNCLIALRKAFADPANATDAKINEYRTFVTDETSE
APLEEQVATLKAKLEELKQVEAQLPPIEEAEKACGDANIEDNEYTDVSFD
DLQFNYEQTVSMFEKKIVYIEAQINEASSGVTAEQMQEFKQSFDAFDGNH
DGILDKLEFRSCLSSMGLIDIDFTGGEDAQYDAIYNNVTKGENGVSFDNY
VQYMKEKNDENPSPEQLNEIFSTIAAGKDSITETDMQKAGMSAEQIEYVK
ANLPQKGDGYDYAAWVKT

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

6sl3 Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6sl3 Calcium modulates the domain flexibility and function of an alpha-actinin similar to the ancestral alpha-actinin.
Resolution	3.1 Å
Binding residue (original residue number in PDB)	D497 N499 D501 I503 D505 E508
Binding residue (residue number reindexed from 1)	D497 N499 D501 I503 D505 E508
Annotation score	4

Enzyme Commision number

	Molecular Function
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0046872	metal ion binding

PDB	RCSB:6sl3, PDBe:6sl3, PDBj:6sl3
PDBsum	6sl3
PubMed	32848067
UniProt	C4LWU6

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Structure of PDB 6sl3 Chain A Binding Site BS01