Structure of PDB 6sk7 Chain A Binding Site BS01

Receptor Information
>6sk7 Chain A (length=285) Species: 650130 (Human rhinovirus 89 ATCC VR-1199) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NPVENYIDSVLNEVLVVPNIQPSTSVSSHAAPALDAAETGHTSSVQPEDM
IETRYVITDQTRDETSIESFLGRSGCIAMIEFNTSSDKTEHDKIGKGFKT
WKVSLQEMAQIRRKYELFTYTRFDSEITIVTAAAAQGNDSGHIVLQFMYV
PPGAPVPEKRDDYTWQSGTNASVFWQEGQPYPRFTIPFMSIASAYYMFYD
GYDGDSAASKYGSVVTNDMGTICVRIVTSNQKHDSNIVCRIYHKAKHIKA
WCPRPPRAVAYQHTHSTNYIPSNGEATTQIKTRPD
Ligand information
>6sk7 Chain D (length=17) Species: 650130 (Human rhinovirus 89 ATCC VR-1199) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
NINYFKDAASSGASRLD
Receptor-Ligand Complex Structure
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PDB6sk7 Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		D66 S69 E71 D127 K249 H250
Binding residue
(residue number reindexed from 1)		D63 S66 E68 D124 K246 H247
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0005198 structural molecule activity

View graph for
Molecular Function
External links
PDB RCSB:6sk7, PDBe:6sk7, PDBj:6sk7
PDBsum6sk7
PubMed31462495
UniProtP07210|POLG_HRV8A Genome polyprotein

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