Structure of PDB 6sar Chain A Binding Site BS01

Receptor Information
>6sar Chain A (length=392) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSIGQEMQMGDYYVRQLRGSAPLINDPLLTQYINSLGMRLVSHANSVKTP
FHFFLINNDEINAFAFFGGNVVLHSALFRYSDNESQLASVMAHEISHVTQ
RHSFTQQNEQEADRIGIQVLQRSGFDPQAMPTFLEKLLDQARYSSRPPEI
LLTHPLPESRLADARNRANQMRPMVVQSSEDFYLAKARTLGMYNSGRNQL
TSDLLDEWAKGNVRQQRAAQYGRALQAMEANKYDEARKTLQPLLAAEPGN
AWYLDLATDIDLGQNKANEAINRLKNARDLRTNPVLQLNLANAYLQGGQP
QEAANILNRYTFNNKDDSNGWDLLAQAEAALNNRDQELAARAEGYALAGR
LDQAISLLSSASSQVKLGSLQQARYDARIDQLRQLQERFKPY
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6sar Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6sar Structure-Function Characterization of the Conserved Regulatory Mechanism of the Escherichia coli M48 Metalloprotease BepA.
Resolution2.18 Å
Binding residue
(original residue number in PDB)		H136 H140 E201 H246
Binding residue
(residue number reindexed from 1)		H93 H97 E109 H154
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.-.-
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6sar, PDBe:6sar, PDBj:6sar
PDBsum6sar
PubMed33106348
UniProtP66948|BEPA_ECOLI Beta-barrel assembly-enhancing protease (Gene Name=bepA)

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