Structure of PDB 6s9a Chain A Binding Site BS01

Receptor Information
>6s9a Chain A (length=312) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRD
FLPTRRPLVLQLVNATTEYAEFLHSKGKKFTDFEEVRLEIEAETDRGISP
VPINLRVYSPHVLNLTLVDLPGMTHVPVGDQPPDIEFQIRDMLMQFVTKE
NCLILAVSPANSDLAHSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDAR
DVLENKLLPLRRGYIGVVNDITAALAAERKFFLSHPSYRHLADRMGTPYL
QKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEESAEQAQRRDEMLRM
YHALKEALSIIG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6s9a Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6s9a Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor.
Resolution1.86 Å
Binding residue
(original residue number in PDB)		H142 D185
Binding residue
(residue number reindexed from 1)		H125 D168
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:6s9a, PDBe:6s9a, PDBj:6s9a
PDBsum6s9a
PubMed34244431
UniProtQ05193|DYN1_HUMAN Dynamin-1 (Gene Name=DNM1)

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