Structure of PDB 6s7t Chain A Binding Site BS01

Receptor Information
>6s7t Chain A (length=706) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQPAGWQSLLSFTILFLAWLAGFSSRLFAVIRFESIIHEFDPWFNYRSTH
HLASHGFYEFLNWFDERAWYPLGRIVGGTVYPGLMITAGLIHWILNTLNI
TVHIRDVCVFLAPTFSGLTSISTFLLTRELWNQGAGLLAACFIAIVPGYI
SRSVAGSFDNEGIAIFALQFTYYLWVKSVKTGSVFWTMCCCLSYFYMVSA
WGGYVFIINLIPLHVFVLLLMQRYSKRVYIAYSTFYIVGLILSMQIPFVG
FQPIRTSEHMAAAGVFALLQAYAFLQYLRDRLTKQEFQTLFFLGVSLAAG
AVFLSVIYLTYTGYIAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTTWV
SFFFDLHILVCTFPAGLWFCIKNINDERVFVALYAISAVYFAGVMVRLML
TLTPVVCMLSAIAFSNVFEHYLGPNIKSIVTMLMLMLLMMFAVHCTWVTS
NAYSSPSVVLASYNHDGTRNILDDFREAYFWLRQNTDEHARVMSWWDYGY
QIAGMANRTTLVDNNTWNNSHIALVGKAMSSNETAAYKIMRTLDVDYVLV
IFGGVIGYSGDDINKFLWMVRIAEGEHPKDIRESDYFTPQGEFRVDKAGS
PTLLNCLMYKMSYYRFGEMQLDFRTPPGFDRTRNAEIGNKDIKFKHLEEA
FTSEHWLVRIYKVKAPDNRETLDHKPRVTNIFPKQKYLSKKTTKRKRGYI
KNKLVF
Ligand information
Receptor-Ligand Complex Structure
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PDB6s7t Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		E101 D103 S402 V403 S404 E405 W605 D606 N623 W677
Binding residue
(residue number reindexed from 1)		E39 D41 S340 V341 S342 E343 W496 D497 N514 W568
Enzymatic activity
Enzyme Commision number 2.4.99.18: dolichyl-diphosphooligosaccharide--protein glycotransferase.
Gene Ontology
Molecular Function
GO:0004576 oligosaccharyl transferase activity
GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0006516 glycoprotein catabolic process
GO:0006986 response to unfolded protein
GO:0018279 protein N-linked glycosylation via asparagine
GO:0036503 ERAD pathway
GO:0043686 co-translational protein modification
GO:0043687 post-translational protein modification
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0008250 oligosaccharyltransferase complex
GO:0016020 membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6s7t, PDBe:6s7t, PDBj:6s7t
PDBsum6s7t
PubMed31831667
UniProtQ8TCJ2|STT3B_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Gene Name=STT3B)

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