Structure of PDB 6s2v Chain A Binding Site BS01

Receptor Information
>6s2v Chain A (length=342) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WNRLEPALAYLAPEERAKVREAYRFAEEAHRGQLRRSGEPYITHPVAVAE
ILAGLQMDADTVAAGLLHDTLEDCGVAPEELERRFGPTVRRIVEGETKVS
KLYKLANLEGAEDLRQMFIAMAEDVRIIIVKLADRLHNLRTLEHMPPEKQ
KRIAQETLEIYAPLAHRLGMGQLKWELEDLSFRYLHPEAFASLSARIQAT
QEARERLIQKAIHLLQETLARDELLQSQLQGFEVTGRPKHLYSIWKKMER
EGKTLEQIYDLLAVRVILDPKPAPTRESQALREKQVCYHVLGLVHALWQP
IPGRVKDYIAVPKPNGYQSLHTTVIALEGLPLEVQIRTREMH
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6s2v Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6s2v A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes.
Resolution2.96 Å
Binding residue
(original residue number in PDB)		H52 H76 D77 D146
Binding residue
(residue number reindexed from 1)		H44 H68 D69 D134
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.6.5: GTP diphosphokinase.
Gene Ontology
Biological Process
GO:0015969 guanosine tetraphosphate metabolic process

View graph for
Biological Process
External links
PDB RCSB:6s2v, PDBe:6s2v, PDBj:6s2v
PDBsum6s2v
PubMed32393900
UniProtQ5SHL3

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