Structure of PDB 6rxs Chain A Binding Site BS01

Receptor Information
>6rxs Chain A (length=218) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPRVLVLTGAGISAESGIRTFRARDPELVQAFANARRRQLQQPEIQPNAA
HLALAKLQDALGDRFLLVTQNLDNLHERAGNTNVIHMHGELLKVRCSQSG
QVLDWTGDVTPEDKCHCCQFPAPLRPHYVWFGEMPLGMDEIYMALSMADI
FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPAS
QVVPEFVEKLLKGLKAGS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6rxs Evolved, Selective Erasers of Distinct Lysine Acylations.
Resolution1.599 Å
Binding residue
(original residue number in PDB)		H147 V188 F190 G191 E192 M193 P194 Y201 H218 V219 Y220 E228 Q245
Binding residue
(residue number reindexed from 1)		H88 V129 F131 G132 E133 M134 P135 Y142 H159 V160 Y161 E169 Q186
Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6rxs, PDBe:6rxs, PDBj:6rxs
PDBsum6rxs
PubMed32187803
UniProtP75960|NPD_ECOLI NAD-dependent protein deacylase (Gene Name=cobB)

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