Structure of PDB 6rxq Chain A Binding Site BS01

Receptor Information
>6rxq Chain A (length=224) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQ
AFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNCDNLHERAG
NTNVIHMHGELLKVRCSQSGQALDWTGDVTPPLRPHVVWFGEMPLGMDEI
YMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEF
AEKYYGPASQVVPEFVEKLLKGLK
Ligand information
>6rxq Chain E (length=9) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GGAKRHRKI
Receptor-Ligand Complex Structure
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PDB6rxq Evolved, Selective Erasers of Distinct Lysine Acylations.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		H147 V188 F190 G191 E192 M193 Y201 H218 V219 Y220
Binding residue
(residue number reindexed from 1)		H108 V138 F140 G141 E142 M143 Y151 H168 V169 Y170
Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6rxq, PDBe:6rxq, PDBj:6rxq
PDBsum6rxq
PubMed32187803
UniProtP75960|NPD_ECOLI NAD-dependent protein deacylase (Gene Name=cobB)

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