Structure of PDB 6rxo Chain A Binding Site BS01

Receptor Information
>6rxo Chain A (length=235) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQ
AFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNCDNLHERAG
NTNVIHMHGELLKVRCSQSGQALDWTGDVTPEDKCHCCQFPAPLRPHVVW
FGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVEL
NLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLK
Ligand information
>6rxo Chain C (length=10) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GGAKRHRKIL
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6rxo Evolved, Selective Erasers of Distinct Lysine Acylations.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		W67 H147 V187 V188 F190 E192 M193 H218 V219 Y220 P221
Binding residue
(residue number reindexed from 1)		W28 H108 V148 V149 F151 E153 M154 H179 V180 Y181 P182
Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6rxo, PDBe:6rxo, PDBj:6rxo
PDBsum6rxo
PubMed32187803
UniProtP75960|NPD_ECOLI NAD-dependent protein deacylase (Gene Name=cobB)

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