Structure of PDB 6rxj Chain A Binding Site BS01

Receptor Information
>6rxj Chain A (length=235) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQ
AFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG
NTNVIHMHGELLKVRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVW
FGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVEL
NLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLK
Ligand information
>6rxj Chain C (length=7) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GGAKRHR
Receptor-Ligand Complex Structure
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PDB6rxj Evolved, Selective Erasers of Distinct Lysine Acylations.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		F60 H147 V188 F190 G191 E192 M193 H218 V219 Y220
Binding residue
(residue number reindexed from 1)		F21 H108 V149 F151 G152 E153 M154 H179 V180 Y181
Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6rxj, PDBe:6rxj, PDBj:6rxj
PDBsum6rxj
PubMed32187803
UniProtP75960|NPD_ECOLI NAD-dependent protein deacylase (Gene Name=cobB)

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