Structure of PDB 6ru0 Chain A Binding Site BS01

Receptor Information

>6ru0 Chain A (length=253) Species: 2336 (Thermotoga maritima)

MLAKRIIACLDVKDGRVVKGTNFENLRDSGDPVELGKFYSEIGIDELVFL
DITAFVEKRKTMLELVEKVAEQIDIPFTVGGGIHDFETASELILRGADKV
SINTAAVENPSLITQIAQTFGSQAVVVAIDAKRVDGEFMVFTYSGKKNTG
ILLRDWVVEVEKRGAGEILLTSIDRDGTKSGYDTEMIRFVRPLTTLPIIA
SGGAGKMEHFLEAFLAGADAALAASVFHFREIDVRELKEYLKKHGVNVRL
EGL

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 6ru0 Chain A Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ru0 Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids.
• Resolution: 2.648 Å
• Binding residue (original residue number in PDB): G82 N103 T104
• Binding residue (residue number reindexed from 1): G82 N103 T104
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 4.3.2.10: imidazole glycerol-phosphate synthase.

Gene Ontology

Molecular Function

• GO:0000107 imidazoleglycerol-phosphate synthase activity
• GO:0005515 protein binding
• GO:0016829 lyase activity

Biological Process

• GO:0000105 L-histidine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6ru0, PDBe:6ru0, PDBj:6ru0
• PDBsum: 6ru0
• PubMed: 31495713
• UniProt: Q9X0C6|HIS6_THEMA Imidazole glycerol phosphate synthase subunit HisF (Gene Name=hisF)