Structure of PDB 6rr7 Chain A Binding Site BS01

Receptor Information

>6rr7 Chain A (length=716) Species: 384505 (Influenza A virus (A/nt/60/1968(H3N2)))

MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSD
FHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGA
EKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSF
TGEEMATKADYTLDEESRARIKTRLFTIRQEMANRGLWDSFRQSERGEET
IEERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNGYIEGKLSQMS
KEVNAKIEPFLKTTPRPIRLPDGPPCFQRSKFLLMDALKLSIEDPSHEGE
GIPLYDAIKCMRTFFGWKEPYIVKPHEKGINPNYLLSWKQVLAELQDIEN
EEKIPRTKNMKKTSQLKWALGENMAPEKVDFDNCRDVSDLKQYDSDEPEL
RSLSSWIQNEFNKACELTDSTWIELDEIGEDVAPIEYIASMRRNYFTAEV
SHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNL
YGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLL
RSAIGQMSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES
SVKEKDMTKEFFENKSETWPIGESPKGVEDGSIGKVCRTLLAKSVFNSLY
ASPQLEGFSAESRKLLLVVQALRDNLEPGTFDLEGLYEAIEECLINDPWV
LLNASWFNSFLTHALR

Ligand information

>6rr7 Chain E (length=11)

gccugcuuuug

...........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6rr7 Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
• Resolution: 3.01 Å
• Binding residue (original residue number in PDB): M477 H510 L511 R512
• Binding residue (residue number reindexed from 1): M477 H510 L511 R512

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075523 viral translational frameshifting
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:6rr7, PDBe:6rr7, PDBj:6rr7
• PDBsum: 6rr7
• PubMed: 31485076
• UniProt: P03434|PA_I68A6 Polymerase acidic protein (Gene Name=PA)