Structure of PDB 6rqt Chain A Binding Site BS01

Receptor Information
>6rqt Chain A (length=1466) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLY
DLALGAFLRNLCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRA
SCLFCHHFRLKSVEVHRYACKLRLLQYGLIDESYKLDEITLGDISSTLLN
ELKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLS
RGKCDNCGMFSPKFRKDGFTKIFETALNEKQITNNRVKGFISTYILSTEV
KNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVLVVPPTRFRLP
SKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLRVIFSRLMNAFVTI
QNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKW
PGATQIQNEDGSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRH
IKNRDVVLMNRQPTLHKASMMGHKVRVLPNEKTLRLHYANTGAYNADFDG
DEMNMHFPQNENARAEALNLANTDSQYLTPTSGSPVRGLIQDHISAGVWL
TSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIFKPYPLWTGKQ
IITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGM
DDLRLTAEGNKWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQ
EILRDNNKSGILDAVTSSKVNAITSQVVSKCVPDGTMKKFPCNSMQAMAL
SGAKGSNVNVSQIMCLLGQQALEGRRVPVMVSGKTLPSFKPYETDAMAGG
YVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQRCLTKQLEGV
HVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPA
KYLGSVSENFQDKLESFLDKNSKGVNEKKFRALMQLKYMRSLINPGEAVG
IIASQSVGEPSTQMTLNTFNVTLGIPRLREIVMTASAAIKTPQMTLPIWN
DVSDEQADTFCKSISKVLLSEVIDKVIVTETTGARSYVIHMRFFDNNEYS
EEYDVSKEELQNVISNQFIHLLEAAIVKEIKKQKRVEANNNMNKVQRDRQ
SAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSI
IRQIPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVA
AVLKTYGVEAARNTIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLA
FNRQGMETSTSSFMKMSYETTCQFLTKAVLDNEREQLDSPSARIVVGKLN
NVGTGSFDVLAKVPNA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6rqt RNA Polymerase I-tWH-Rrn3-DNA
Resolution4.0 Å
Binding residue
(original residue number in PDB)		E464 R481 T1013 S1014 G1017 Y1018 E1616
Binding residue
(residue number reindexed from 1)		E384 R401 T933 S934 G937 Y938 E1419
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:1990841 promoter-specific chromatin binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
GO:0006361 transcription initiation at RNA polymerase I promoter
GO:0006362 transcription elongation by RNA polymerase I
GO:0006363 termination of RNA polymerase I transcription
GO:0042254 ribosome biogenesis
GO:0042790 nucleolar large rRNA transcription by RNA polymerase I
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005736 RNA polymerase I complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rqt, PDBe:6rqt, PDBj:6rqt
PDBsum6rqt
PubMed31804486
UniProtP10964|RPA1_YEAST DNA-directed RNA polymerase I subunit RPA190 (Gene Name=RPA190)

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